{"id":86,"date":"2009-05-12T15:56:10","date_gmt":"2009-05-12T22:56:10","guid":{"rendered":"http:\/\/www.fcihr.ca\/prize\/prizewinners\/prof-sir-john-bell"},"modified":"2012-06-01T13:32:33","modified_gmt":"2012-06-01T20:32:33","slug":"prof-sir-john-bell","status":"publish","type":"page","link":"https:\/\/www.fcihr.ca\/prize\/prizewinners\/prof-sir-john-bell","title":{"rendered":""},"content":{"rendered":"<p><a href=\"http:\/\/www.fcihr.ca\/prize\/wp-content\/uploads\/2012\/05\/citation-2009-friesen-prize-john-bell.pdf\" title=\"Citation - 2009 Friesen Prize - John Bell\"><img decoding=\"async\" src=\"http:\/\/www.fcihr.ca\/prize\/wp-content\/uploads\/2012\/05\/citation-2009-friesen-prize-john-bell.JPG\" alt=\"Citation - 2009 Friesen Prize - John Bell\" width=\"646\" \/><\/a><br \/>\n<a href=\"http:\/\/www.fcihr.ca\/prize\/videocast.php\"><img decoding=\"async\" src=\"\/img\/watchvid_notlive.jpg\" alt=\"watch live video cast\" class=\"alignright\" \/><\/a><\/p>\n<h3>A Canadian<br \/>\nat the top of UK academic medicine<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.fcihr.ca\/prize\/wp-content\/uploads\/2009\/05\/john-bell-photo.jpg\" alt=\"john-bell-photo.jpg\" align=\"right\" height=\"201\" width=\"204\" \/><\/p>\n<h3>THE LANCET<\/h3>\n<p>Geoff Watts, Academy of Medical Sciences; Vol 372 Nov. 22, 2008, 1801<\/p>\n<p align=\"justify\">What with the knighthood, the Regius Chair of Medicine at Oxford University, and the Presidency of the Academy of Medical Sciences, to ask John Bell if being a Canadian by birth\u2014and still very much by accent\u2014has hindered his UK medical career would be faintly absurd. So, conversely, has it brought any advantages? Yes, he says. For one thing he\u2019s sidestepped traditional British pigeonholing based on schooling, parentage, and the like. And for another there\u2019s the can-do, entrepreneurial \u201cfrontier spirit\u201d that tends to go with Canadian nationality: \u201cThis has got to work, so let\u2019s be optimistic and make it work.\u201d Which is what he\u2019s been doing ever since he first arrived in the UK in 1975.<\/p>\n<p align=\"justify&gt;Despite his parents\u2019 occupations\u2014haematology and pharmacy\u2014medicine was something of an afterthought for the young Bell. \u201cI didn\u2019t thrive on science at school because what you get taught is the textbook.\u201d At that stage he didn\u2019t see science as a continuing process of discovery. \u201c The best bit is when you get in a lab and start asking questions yourself.\u201d Which is what has always driven him. \u201cI\u2019m really interested in innovation and discovery. As a scientist I like to be the first person to have made some observation, even a relatively trivial one. It\u2019s one of the things that gives you a buzz in science. And I\u2019m also excited by the idea of making something useful out of discoveries.\u201d With a track record not only in research but in helping to set up several biotech companies, Bell has done both. At a time when genetics, his main area of interest, was still focused on rare single gene disorders, he already believed it could play a wider role. He was the Founder of the Wellcome Trust Centre for Human Genetics at Oxford University, and has been among those clinician researchers who are now showing the practical utility of insights into the multiple genetic influences in heart disease, diabetes, and other common disorders.&lt;\/p&gt; &lt;p align=\">It was a Rhodes scholarship that brought Bell from Edmonton, his home town, to Oxford University where his intention was to do preclinical sciences before returning to Canada. \u201cAll I can remember of my first months in Oxford is that they never turned the heating on in the Bodleian Library despite the frost on the windows. The idea then of staying in this country would probably have horrified me.\u201d<\/p>\n<p align=\"justify\">He was nonetheless persuaded to remain in the UK for his clinical training\u2014following which he was again tempted to stay on, this time by his mentor, the then Nuffield Professor of Medicine David Weatherall.<\/p>\n<p align=\"justify\">In 1982, did eventually return to North America, though not to Canada but to California: to immunologist Hugh McDevitt\u2019s Stanford University laboratory. He worked on blood, a tissue chosen in part for its eminently practical virtue of accessibility. For using molecular tools to analyse the immune system, Stanford then was the place to be. \u201cI arrived at the beginning of the recombinant DNA revolution in America. They were applying it across a whole variety of things, but in McDevitt\u2019s lab it was to the histocompatibility antigens.\u201d<\/p>\n<p align=\"justify\">California was seductive but, Bell adds, parochial. He stayed 5 years before Oxford, in the form of Weatherall\u2019s nascent Institute of Molecular Medicine, drew him back to the UK. He\u2019d reckoned on staying for another 5 years. But things went well, he started to produce good scientific work, so he stayed on\u2014again. (Bell has been proved to be a serial lingerer.) In 1992, aged around 40 years, he was appointed to succeed Weatherall as Nuffi eld Professor of Clinical Medicine. And in 2002, just when he was again wondering if it was time to be gone, yet another opportunity presented itself: the Regius professorship of medicine, this too vacated by Weatherall.<\/p>\n<p align=\"justify\">In a career studded with awards and achievements, what gives him the greatest satisfaction? The success of helping to lead genetics out of its traditional concentration on rare, single gene disorders, he says, and into the arena of common diseases in which many genes may play a part. It was a development he foresaw in a paper published in the late 1990s: a prediction dismissed by a lot of his peers. They simply did not believe that gene testing would have any practical utility in circumstances where genetic influences were many in number and quite possibly complex in their interaction. While personalised medicine is an aspiration that continues to prompt scepticism, to Bell it\u2019s merely a question of how soon and how common.<\/p>\n<p align=\"justify\">And his biggest mistake? \u201cIn the early days of the Nuffield Chair I got myself embroiled in trying to fix the Health Service in the hospital. That was not smart. But in my early 40s, when I\u2019d made a few hits, I was over-confident.\u00a0 Sometimes you just have to let things evolve.\u201d<\/p>\n<p align=\"justify\">Elected to the Presidency of the Academy of Medical Sciences in 2006, Bell can still bring an outsider\u2019s eye to the enterprise. The fact that he likes most of what he sees of UK academic medicine\u2014not least the momentum generated by innovative researchers able to carry it through periods of funding famine\u2014is part of what\u2019s kept him in the UK.\u00a0 He also thinks the Academy, currently celebrating its 10th anniversary and planning a move to new premises, is in good shape. As Bell points out, he\u2019s now lived longer in the UK than in Canada. Does this mean he\u2019s here for good? At least until retirement, he says\u2014but then laughs. \u201cYou can never be sure. If the right opportunity came, I\u2019d definitely get on a boat or a bike or whatever it took.\u201d<\/p>\n<p><a href=\"http:\/\/www.fcihr.ca\/prize\/videocast.php\"><\/a><a href=\"http:\/\/www.fcihr.ca\/prize\/videocast.php\"><\/a><a href=\"http:\/\/ukincanada.fco.gov.uk\/en\/news\/?view=News&amp;id=20917137\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.fcihr.ca\/wp-content\/uploads\/2009\/09\/british-high-commission-web-site-leaders-breakfast-september-22-2009.JPG\" alt=\"british-high-commission-web-site-leaders-breakfast-september-22-2009.JPG\" height=\"365\" width=\"635\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A Canadian at the top of UK academic medicine THE LANCET Geoff Watts, Academy of Medical Sciences; Vol 372 Nov. 22, 2008, 1801 What with the knighthood, the Regius Chair of Medicine at Oxford University, and the Presidency of the Academy of Medical Sciences, to ask John Bell if being a Canadian by birth\u2014and still [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":23,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-86","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.fcihr.ca\/prize\/wp-json\/wp\/v2\/pages\/86","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fcihr.ca\/prize\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.fcihr.ca\/prize\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.fcihr.ca\/prize\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fcihr.ca\/prize\/wp-json\/wp\/v2\/comments?post=86"}],"version-history":[{"count":0,"href":"https:\/\/www.fcihr.ca\/prize\/wp-json\/wp\/v2\/pages\/86\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.fcihr.ca\/prize\/wp-json\/wp\/v2\/pages\/23"}],"wp:attachment":[{"href":"https:\/\/www.fcihr.ca\/prize\/wp-json\/wp\/v2\/media?parent=86"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}